This brief guidance has been produced by the Royal College of Pathologists following the outbreak of the COVID-19 infection in China. It is produced to aid mortuary staff and pathologists in deciding if a post mortem is appropriate on a possible COVID-19 death and to advise them on the possible risks associated with such a case and how to reduce these risks. It also covers diagnosis of COVID-19 at post mortem. This briefing is for mortuary staff who are potentially exposed to material including body fluids from cadavers in the mortuary.