This study analyses relevant obligations arising from the International Convention for the Protection of All Persons from Enforced Disappearance (ICPPED) with regard to disappeared migrants and refugees. It elaborates the Convention’s contribution to protect migrants and refugees from becoming victims of enforced disappearance and to support relatives in their search for disappeared migrants and refugees. The study also points to issues that would benefit from further interpretation by the CED to assist States in performing their obligations as best as possible.