The problem of the missing persons phenomenon in Brazil in the 21st century has become apparent, and the responses to the issue are still under development. The relatively new field of forensic anthropology and its trained professionals occupy an essential place in the investigation of cases of missing and unidentified individuals. The development of forensic anthropology in Brazil is unique among Latin American countries, who improved their expertise during the investigations of political crimes that occurred between the 1960s and 1980s in most places. The qualifications and the paths to become a forensic anthropologist in Brazil are different from other professionals who work in the field worldwide. This article addresses the issue of missing person investigations and details the work of forensic anthropologists in such cases in Brazil.